Transcriptional and Post-transcriptional Regulation in TGF- -mediated epithelial-mesenchymal transition
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of epithelial-mesenchymal transition.
It has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal phenotype, is a key event occurring during normal development and pathological processes. Multiple extracellular stimuli and transcriptional regulators can trigger EMT, but how such dist...
متن کاملTranscriptional and Epigenetic Regulation of Epithelial- Mesenchymal Transition
Tan, E.-J. 2013. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 928. 51 pp. Uppsala. ISBN 978-91-554-8734-8. The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, diff...
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BACKGROUND Epithelial-mesenchymal transition (EMT) changes polarized epithelial cells into migratory phenotypes associated with loss of cell-cell adhesion molecules and cytoskeletal rearrangements. This form of plasticity is seen in mesodermal development, fibroblast formation, and cancer metastasis. METHODS AND FINDINGS Here we identify prominent transcriptional networks active during three ...
متن کاملTranscriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization
PURPOSE To investigate the transcriptional factors associated with epithelial-mesenchymal transition (EMT) in choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). METHODS Paraffin sections of CNV obtained from patients with AMD (n = 12) were stained for transcriptional factors related to EMT, i.e., Snail, Slug, SIP1, and Twist. As a control, postmortem secti...
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Cervical carcinoma is a most prevalent cancer in women worldwide. The metastasis is one of the major issues for late-stage cervical carcinoma in patients. Epithelial-mesenchymal transition (EMT) has been implicated in cervical carcinoma progression and metastasis. During EMT, cervical carcinoma cells lose epithelial features and gain a mesenchymal phenotype. The EMT has been identified to be re...
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ژورنال
عنوان ژورنال: Journal of Biochemistry
سال: 2012
ISSN: 0021-924X
DOI: 10.1093/jb/mvs040